Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death
نویسندگان
چکیده
منابع مشابه
Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death.
Precancerous cells that enter S phase without appropriate growth and viability factors undergo programmed cell death, suggesting that apoptosis may help guarantee organismic integrity [Evan, G. & Littlewood, T. (1998) Science 281, 1317-1322]. However, the connection between proliferation and cell death has remained unclear. Here, we show that the positive cell cycle regulator cyclin D3 [Matsush...
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Caspase-mediated apoptosis is the death program of choice in many developmental and physiologic settings (Kerr et al., 1972; Strasser et al., 2000; Kaufmann and Hengartner, 2001). It would, however, be very dangerous for the organism to depend on a single protease family for clearance of unwanted and potentially dangerous cells. Indeed, the exclusive role of caspases in the execution of program...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.072290599